![]() You may have to select a menu option or click a button. Follow the instructions for disabling the ad blocker on the site you’re viewing.You may have more than one ad-blocker installed. You’ll usually find this icon in the upper right-hand corner of your screen. Click the icon of the ad-blocker extension installed on your browser. /rebates/2fw2fwomens-jordan-1-shoes-4fokyz5e1圆zy7ok&.When it turns gray, click the refresh icon that has appeared next to it or click the button below to continue.Click on the large blue power icon at the top. Air Jordan 1 Retro High OG University Blue Air Jordan, sneakers, Air Jordan 1 3.5 411 4 373 4.5 399 5 396 5.5 519 6 493 6.5 514 7 407 7.5 384 8 337 8.Click the UBlock Origin icon in the browser extension area in the upper right-hand corner.It will turn gray and the text above will go from “ON” to “ OFF”. Discover more latest Shoes collections online. Click on the “ Ad-Blocking” button at the bottom. Shop now for Jordan Shoes in Dubai, UAE at Nike's official online store.Jordan 1 Retro High OG Grade School Shoes Black - Royal Blue - White NZ200.00. Jordan 1 Retro High OG Men Shoes Black - Royal Blue - White NZ280.00. Jordan Metal Jumpman Cap Unisex Caps Black - Black - Gunmetal NZ45.00. Click the Ghostery icon in the browser extension area in the upper right-hand corner. Jordan Metal Jumpman Cap Unisex Caps Gym Red - Black - Gunmetal NZ45.00.Switch off the toggle to turn it from “ Enabled on this site” to “ Disabled on this site”.Click the AdBlocker Ultimate icon in the browser extension area in the upper right-hand corner.“ Block ads on – This website” switch off the toggle to turn it from blue to gray.Click the AdBlock Plus icon in the browser extension area in the upper right-hand corner. Light Blue - Custom Nike Air Jordan 1 mid - AJ1 Mid (495) Sale Price 373.28 373.28 622.14 Original Price 622.Refresh the page or click the button below to continue.Under “ Pause on this site” click “ Always”.Click the AdBlock icon in the browser extension area in the upper right-hand corner.Sneakerheads were eager to get their hands on the ‘banned’ basketball shoes, and it didn’t take long for sales to soar to new heights, much like the Jumpman silhouette (the Jordan brand’s logo).Adblock Adblock Plus Adblocker Ultimate Ghostery uBlock Origin Others The punishment for breaking this rule was a $5,000 fine, which Nike paid on behalf of His Airness.Īfter its public release in 1985, the Air Jordan 1 became an immediate hit, elevated by the rule-breaker reputation it had achieved. The AJ1 gained media attention when Jordan took them for a spin across several professional games, breaking the NBA’s long-standing rule that all sneakers worn by players needed to be predominantly white-the AJ1 was white, red, and black. ![]() This deal led to the creation of none other than the Nike Air Jordan 1 high top, a sneaker that would go on to become a legend both on and off the court. In 1984, basketball player Michael Jordan (who at the time was still a newcomer on the NBA scene, playing for the Chicago Bulls) signed a historic deal with the Swoosh brand. Buy and sell StockX Verified Jordan 1 Mid Laser Blue Mens shoes 554724-141 and thousands of other Jordan sneakers with price data and release dates. Since the creation of the OG AJ1, the sneaker has continually impressed with its classic silhouette and premium-quality leather upper, appealing to fans of the NBA and your everyday trendsetters. This iconic silhouette is available in low, mid, and high styles, and there are loads of unique colourways, including black and white. Embrace the retro aesthetic with the Air Jordan 1 range at JD Sports Australia.
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![]() ![]() I’ll walk you through how you’d use wood ash to solve each of these common everyday household problems.Įven if you don’t have a “homestead” or a back garden, there are plenty of ways to use wood ashes around the house, indoors, and out. Some of the most common modern ways to use wood ashes include: (Or, you can just scroll down and read them all.) Primitive and Survival Uses for Wood AshĬlick on any of those links, and it’ll jump you to the right place in the article.There are a lot of uses for ash, so I’ve broken them down into convenient categories for you: Wood ash is little more than the remaining minerals after burning wood, and fireplace ashes contain calcium and all manner of other things that can be handy around the house, if used properly. That’s way too much for any single-use, so we’ve had to find creative ways to use wood ash, when it would otherwise be a waste product. That means we have around 30-40 gallons of wood ash in the spring. Still, cold Vermont winters mean that we burn roughly 4 cords of hardwood each year, or 6 to 8 cords of softwood which has a lower BTU.Ī cord of hardwood produces roughly 5-8 gallons of wood ash, or about 20 to 25 pounds of ashes per cord. ![]() To save on wood (and work), we only heat our house to around 62 degrees day and night. Our homestead is relatively small by modern standards (~1200 sq feet), and the walls are nearly a foot thick and super-insulated. If you’re heating with wood, there’s always plenty of wood ash to go around, and you may find yourself wondering what to do with fireplace ashes. Historically, wood ash was an asset, and there are still plenty of creative ways to use wood ash in your modern home, garden, and even your kitchen! Wood ash from your fireplace, woodstove, or outdoor boiler may seem like a waste product, but there are a surprising number of uses for wood ash. ![]() 1A), Prop 65 y OEHHA RELs óxido de cobalto (II) y dióxido de titanio, listados en Prop 65 e IARC Carcinogens - 2B. Copyright 2023 Norwich Camping & Leisure Design & Development by InnerShed. May be used with Weber Portable Cart model 6557. 1B) monóxido de níquel, listado en EC Annex VI CMRs (cat. Weber Summit S-670 Gas Grill - Stainless Steel. The Weber Q 1400 grill is fully featured, yet space-saving and portable just the ticket for grillers living in condos or any residence where restrictions govern gas and charcoal grill usage. This product contains Diboron Trioxide which is listed in EC Annex VI CMRs - Cat.1B Nickel Monoxide which is listed in EC Annex VI CMRs - Cat.1A, Prop 65, and OEHHA RELs Cobalt (II) Oxide and Titanium Dioxide which are listed in Prop 65 and IARC Carcinogens - 2B at the following website: Įste producto contiene trióxido de diboro, listado en EC Annex VI CMRs (cat. ![]() ( Wash hands after handling this product.)Ĭombustion by-products produced when using this product contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. Check out the Q 1200 1-Burner Portable Tabletop Propane Gas Grill in Titanium with Built-In Thermometer available in this collection.Proposition 65 Warning: Handling the brass material on this product exposes you to lead, a chemical known to the State of California to cause cancer, birth defects or other reproductive harm. The Best Two-Burner Gas Grill: Weber Spirit II E-210. The Best Overall Gas Grill: Weber Spirit II E-310. The Best Beginner-Friendly Charcoal Grill: Weber Performer Deluxe Charcoal Grill 22. What collections are available within Weber Portable Gas Grills? Shop grills and essentials, including grill covers, thermometer, briquettes and more from the Weber Portable Grills Collection by Weber. Camping & Recreation Outdoor Activities Outdoor Living Inspiration We can assemble your BBQ for only 160. The Best Overall Charcoal Grill: Weber Original Kettle Premium 22 Grill. Check out the best-selling product, the Traveler Portable Propane Gas Grill in Black. We carry Weber Portable Gas Grills with various features such as Grease Pan, Tool Holder and Heat Thermometer. On the other hand, smokers use a much lower internal temperature, but the cooking process runs for an extended time to add true barbeque flavor to the meat. Camping & Recreation Outdoor Activities Outdoor Living Inspiration We can assemble your BBQ for only 160. Grilling is a cooking technique done at high temperatures and for a shorter period. What is the difference between a grill and a smoker? The major difference between a grill and a smoker is the temperature and time required for the cooking process. What are some of the most reviewed products in Weber Portable Gas Grills? Some of the most reviewed products in Weber Portable Gas Grills are the Weber Q 1200 1-Burner Portable Tabletop Propane Gas Grill in Titanium with Built-In Thermometer with 3,848 reviews, and the Weber Q 1200 1-Burner Portable Tabletop Propane Gas Grill in Orange with Built-In Thermometer with 3,847 reviews. What's the price range for Weber Portable Gas Grills? The average price for Weber Portable Gas Grills ranges from $40 to $500. What are the shipping options for Weber Portable Gas Grills? All Weber Portable Gas Grills can be shipped to you at home. Weber Gas Grills Explore Webers best gas grills - crafted for grill masters, designed for ease to elevate backyard gatherings with friends & family. Check out the Traveler Portable Propane Gas Grill in Black. Is there a Black product available in Weber Portable Gas Grills? Yes, we carry a Black product in Weber Portable Gas Grills. /rebates/2fb2fOutdoors-Outdoor-Cooking-Grills2fWeber2fN-5yc1vZbxazZ1ls&. An Olympus and Canon shooter, he has a wealth of knowledge on cameras of all makes – and a fondness for vintage lenses and instant cameras. View 4 Images View gallery - 4 images After initially testing the waters with a short crowdfunding campaign back in July, Canons Ivy Rec Clippable Outdoor Camera is now going on. ![]() This has led him to being a go-to expert for camera and lens reviews, photo and lighting tutorials, as well as industry news, rumors and analysis for publications like Digital Camera Magazine, PhotoPlus: The Canon Magazine, N-Photo: The Nikon Magazine, Digital Photographer and Professional Imagemaker, as well as hosting workshops and talks at The Photography Show. He also serves as a judge for the Red Bull Illume Photo Contest. In this time he shot for clients like Aston Martin Racing, Elinchrom and L'Oréal, in addition to shooting campaigns and product testing for Olympus, and providing training for professionals. The editor of Digital Camera World, James has 21 years experience as a journalist and started working in the photographic industry in 2014 (as an assistant to Damian McGillicuddy, who succeeded David Bailey as Principal Photographer for Olympus). It 'boasts' electronic image stabilization, but all this does (again, I'M NOT EXAGGERATING, look at the sample below) is turn your video into Jell-O and poke it until it wobbles so much that you'll probably get nauseous watching it back. The Rec can shoot 1080p movies at 60p, but you should never do this. Trust me, and I'm not even tossing out hyperbole here, the old Nokia phone you keep in your junk drawer for sentiment's sake very likely takes better quality photos than this camera.ĭetails are muddy, colors just leech into each other, highlights are horrible… and again, you don't know what's going to be sharp, but "sharpness" is a relative term. it features a 13-megapixel 1/3-inch CMOS sensor. The Ivy Rec features a 13MP sensor, but it's one of the worst 13MP sensors you'll ever use. images courtesy of canon the IVY REC, ‘clippable, go anywhere camera’ is an ultra-compact point-and-shoot featuring a built-in carabiner. Will I get a headshot, or a full body shot? Will my subject's face be in focus, or will the trees behind her be in focus? Will my thumb be in the frame? Will my image be horribly overexposed, or horribly underexposed? ![]() ![]() There's a certain thrill to it, of course. Unfortunately, that means you have no control over anything – coupled with having no idea what's in your frame, and no screen to check what you've just shot, taking photographs is like spinning a roulette wheel. Bottom line, you could put together a fairly compact 3D camera, potentially with a tight and/or variable interocular, but even the button sync would be hit or miss and the image quality is only so-so. View full size to see the yucky image quality (Image credit: James Artaius)Įverything is fully automatic, from the AF to exposure, because the whole idea is that you just point and shoot. So the Canon Ivy Rec arrived and I tried some test photos along with my W3 for comparison. … and this is what it looked like on the Canon Ivy Rec. ![]() “Just started using this, and my baby and I are loving it so far. While this wasn’t initially possible when the Sound and Light first released, it’s now easy to operate your sound machine via the main Nanit app. ![]() If you’re a Nanit monitor user and hoping to integrate this Sound and Light within your monitor app, you’re in luck. The Sound and Light is powered through an app and runs either on a rechargeable battery (helpful for on the go or if your power goes out) or with a power adaptor. The digital clock display is a nice addition and extra useful during nighttime feeds. ![]() You can customize both the sounds and the night light’s color and brightness to create whatever combo your baby likes best, including routines for bedtime, wakeup and naps. Sound options include white noise, nature sounds, lullabies and more. This two-in-one sound machine is a white noise machine and a programmable night light all rolled into one. Nanit’s Sound and Light is another phone-friendly, multifunction sound machine worth a look, especially if you already use the brand’s popular smart baby monitor. USB charging (cable included, USB power adapter wall plug not included) Other portable sound machines don’t compare to this one!” -Jennifer M. The plug-in charger makes it super easy to charge when using or not using! The most important thing for me was the sound quality. “The Hushh Compact Sound Machine is compact and easily stowed away in my diaper bag. The battery lasts about eight hours, so if you’re using it overnight, you’ll want to keep it plugged in. There’s no timer on this sound machine, so you’ll need to switch it off manually. The volume is adjustable, and when it’s time to recharge the Hushh, you can plug the USB cable into your laptop or phone. There are three sound options: standard white noise, a deeper-toned white noise or the sound of surf. It comes with a clip so you can fasten it onto the stroller or car seat and even has a small, amber-colored night light. Measuring only 3.5 inches and cord-free, the Hushh is made for when you need white noise on the go. Additional Specs Dimensionsġ1 sound options and a nightlight with a “rainbow” of colors And I know I’ll be using the toddler alarm clock once my son gets a little older and we need to help him stay in bed longer in the morning.” -Jen L. (Perfect for times when I need to hike up the volume quickly, like when my older son runs upstairs to play while the baby is napping or if a landscaping truck pulls onto my street.) The nightlight was perfect for overnight feeds. I love all of the different sound features and that I can control everything from my phone. “At first I wasn’t sure I needed a sound machine with all of these features, but after using it for over a year, I’m totally hooked. The Hatch Restore is a sleep assistant for parents, combining a sound machine, sunrise alarm, smart light, meditation app and an alarm clock all in one. What’s Worth Consideringĭon’t let your baby or toddler have all the relaxing sleep fun. You can also access bedtime stories, exclusive playlists and other custom content through a Hatch Sleep Membership. It can help you establish a bedtime routine and grow with your child from the baby days through the big-kid years. This do-it-all sleep device is fully customizable and programmable with lights and different types of noise and even has a battery backup in case you lose power. Sound machine + night light + time-to-rise clock all in one, all controlled from your smartphone? Genius.
![]() ![]() AUTOMATICALLY IDENTIFY FACES IN PHOTOSĪI Enhancer, also known as AI Photo Enhancer, can instantly and automatically recognize your face in any photograph you take, whether it is of you or a group of people. You are free to make any changes to the brightness, saturation, and other settings that you see fit to achieve the desired look. You can also change the image’s color to reflect your personal preferences by applying the best effect for yourself. You have the explicit right to edit any image to make it clearer or blurrier, depending on the individual’s usage and goals for the image. ![]() If the resolution is increased by 200%, 500%, or even more, every user will have access to crisp and beautiful images. You can either repair or replace older images with more recent versions of the same image to make them more appealing.ĪI Enhancer and AI Photo Enhancer allow users to easily increase the image resolution of any image they choose, ensuring that the final product has both the clarity and resolution that the user desires. The application in question produces results of such high quality that you will be astounded by them. Photos taken ten or even twenty years ago can be converted into vibrant, smooth images with HD quality. You can breathe new life into your images by utilizing the advanced technology included in the application. Users of AI Enhancer or AI Photo Enhancer can restore and repair photographs that have become faded or scratched to their original glory and beauty. You will be able to appreciate the many stunning visual products it provides because it employs cutting-edge AI technology. The efficiency with which low-quality images can be converted to high-quality HD is unparalleled. This application will allow you to enhance and correct blurry photos quickly. ![]() Before using this solution, you'll need to make sure that you have made at least one local copy of your iPhone data. Tap on your name > Hit iCloud > Disable the App's backup option.ĭisabling useless iCloud backups is another solution to speed up iPhone backup. Go to the Settings app on your iPhone or iPad. If you don't want to delete apps from the iPhone or iPad, then you can go to your Settings to disable apps that occupy a lot of space. If that doesn't work, try to remove some unused files like photos, videos, and audios from your device. To tackle this issue, you can try to delete some unwanted apps on iPhone. Remove unused apps or unwanted files from your iPhoneīacking up too many heavy-data apps may also slow down the backup speed. While if you back up your iPhone regularly, you will find each backup can be done more quickly. If you back up your iPhone to the computer with iTunes or iCloud for the first time, a slow iPhone backup is almost inevitable since all the files on your iPhone are new to iTunes or iCloud. If you come across iPhone taking forever to backup to computer or iPhone backup taking 12 hours or more, you might want to try this reliable EaseUS software. Furthermore, it also serves as a Twitch clip downloader that allows you to download wanted videos from Twitch with ease. Especially if you have many photos, videos, and media files to back up, this tool can transfer them without any lag. As a versatile iOS data manager, it can back up all popular iOS data from your iPhone to the computer at an extraordinary speed. Now that the speed of an iCloud/iTunes backup is limited by so many factors, why not replace them with a faster backup tool? If you're looking for one, the iPhone data transfer tool - EaseUS MobiMover is a good choice. ![]() Using iTunes/iCloud alternatives to back up iPhone X/8/7/6 Now, you can follow the step-by-step instructions to get the job done. Here are some solutions to fix the one backup taking forever" issue. Solutions to Fix "iPhone Backup Taking Forever" Issue iCloud backup stuck on estimating time remaining.Īfter knowing why is your iPhone backup taking so long, you can now gain some feasible solutions to speed up iPhone backup by reading the following text.The initial backup of a new device will take considerably longer than future backups.Too many media files like photos, videos, and so on.There are a couple of reasons why your iPhone backup taking forever using iCloud or iTunes. Why is iCloud backup taking forever? That's a good question. But overall, iTunes is faster than iCloud because the backup is stored locally on your computer, whereas iCloud backups are stored on a remote machine in the "cloud." Part 2. Similar to iCloud, the iTunes backup speed is also determined by various factors like data amount, network speed, and device condition. If you back up your device regularly, it won't take too long to back up. And sometimes iCloud backup time keeps increasing during the process. Usually, an iCloud backup takes approximately 30 mins to 2 hours to complete the process, depending on the number of files to backup, internet connection, and device condition. Let's take iTunes and iCloud, for example. And different backup services offer different speeds for backing up. Usually, a backup speed is decided by various factors, including data type, data amount, device condition, internet condition, etc. ![]() How long does it take to backup iPhone to iCloud or iTunes? This is a common question frequently asked by users. How Long Does It Take to Backup an iPhone If worst comes to worse, I'll back up to an internal drive, and then just file copy the backup to my external drive I assume this is OK. I'll try to wait until it completes, then I'll try again with HDM 15. It's been 48 hours so far, and still not done based on the size of the backup created so far, I'm about 75& complete. Now, I have switched to HDM 16.5 ("advanced"), and am backing up the same 450 GB SSD drive to to a USB 3.0 external drive. I used to use HDM 15 (purchased copy) to backup up my C: drive, about 450 GB on an Intel SSD, to a local internal disk took about 5 hours. ![]() I've used other programs that didn't take any where near that long! I also made a migration disk backup of the same system and don't believe it took anywhere near that long! I guess the best thing is to use Paragon to do the migration part and use Easeus or some other software to do a system image. Incredible! I could not believe how long it took! It took 19 hours! That's right, 19 hours, to make a backup image of my 1 TB Windows 8.1 system. I ran into the same thing! But using Paragon Hard Disk Manager. Retouch parts on AI generated people or images.Here are some great and practical use cases and ideas for editing your images with AI text prompts: Generative Fill is ideal for retouching people and changing hairstyle using AI What are the best use cases for Generative Fill?ĪI can create some amazing images, however it can often struggle to produce a decent picture sometimes. While Photoshop’s Generative Fill tool can be a bit overwhelming for beginners due to its extensive feature set, Pincel boasts a user-friendly interface designed to cater to users of all levels. ![]()
![]() (15:20) – Lorenzo in the ring and Lorenzo outside are two different people. (12:32) – The switch to bare knuckle fighting is. (11:08) – Lorenzo takes no joy in hurting his opponent. (9:54) – The enemy within is real according to Lorenzo. (9:32) – Lorenzo reveals that he advocates for suicide prevention. ![]() (8:56) – Physically strong people are mentally strong people too according to Lorenzo. (8:30) – Lorenzo discusses the danger of not being ready for a fight mentally. (6:34) – Lorenzo shares his views on mental health evaluations for fighters. (5:50) – The correlation between mental and physical health. (4:45) – Mental health wasn’t discussed in Lorenzo’s house. (4:04) – Social anxieties caused him to go deep into his craft and become diverse. (2:13) – He was targeted by other kids and that was a trigger for him. (2:00) – Lorenzo has always been a fighter. “For the most part, my training is my therapy.” – Lorenzo, (30:24) “It doesn’t matter how you try to hurt someone, it’s going to hurt.” – Lorenzo, (13:34) Both are integral parts of our lives and today, we tackle them head on with a man who only knows one direction … forward! This is a fascinating conversation and one that will undoubtedly inspire you to move to new heights in your life from both a physical and more importantly, a mental state. “I think that we really should take into consideration the mental health of our athletes more.” – Lorenzo, (6:22) I sit down with him to discuss some of the struggles he’s had to overcome, his approach to life, his sport, and how he maintains a healthy mental state. He’s Lorenzo Hunt, also known as, “The Juggernaut” and one of the greatest fighters of this or any other generation. Today, I spend time talking to a man who stands atop the bare-knuckle fighting world, roundly recognized as the premier talent in that sport. “My father was like super-cool and taught me martial arts, so he was like my big brother more than my dad.” Lorenzo, (3:13) It’s a tough sport, ruled by tougher men, and one that’s on the rise in the global sports community. Those rounds can seem like an eternity for a boxer, filled with intensity, blood, sweat, and tears. It’s a tough sport and you have to be wired a little differently to step into a ring where you’re reliant on yourself, not a teammate or a coach on the sideline for success. Bare-knuckle fighting is not for the faint of heart. ![]() ![]() We applied THISTLE together with LeafCutter and QTLtools to the largest publicly available brain transcriptomic data ( n = 2,865) with genotype data to detect sQTLs and integrated the sQTL summary statistics into GWAS for 12 brain-related traits (including diseases) of large sample sizes ( n = 51,710–766,345) to prioritize genes associated with the traits through genetic regulation of splicing. Nevertheless, the limited number of sQTLs detected by sQTLseekeR motivated us to develop a more powerful transcript-level sQTL method, THISTLE. Recognizing the differences between transcript- and event-level sQTL mapping strategies (Section 1 of the Supplementary Note), we intended to combine the two strategies with state-of-the-art tools, that is, RSEM 36 and sQTLseekeR 27, 37 for transcript-level analysis and LeafCutter 31 and QTLtools 38 for event-level analysis, to increase the yield of sQTLs. ![]() We focused our study on the brain because of data availability and the considerable links of sQTLs to neurodegenerative diseases such as Alzheimer’s disease (AD) 32, schizophrenia 33 and Parkinson’s disease (PD) 34, 35 reported recently. In this study, we aimed to investigate the genetic control of RNA splicing by generating the largest collection of sQTLs to date and describing their role in complex trait variation. ![]() Depending on how alternative splicing variation is quantified, sQTL mapping strategies can be broadly classified into two categories 22, that is, transcript-level 23, 24, 25, 26, 27 or event-level 28, 29, 30, 31, each favoring different types of splicing events (Section 1 of the Supplementary Note). These results motivated us to investigate the role of sQTLs in complex traits using a larger dataset. For example, there are observations showing that sQTLs are largely independent of eQTLs 6, 19, 20 and hypothesized to be one of the major contributors to genetic risk of disease 20, whereas a recent study showed that the contribution of sQTLs to trait heritability is not statistically significant conditional on eQTLs 21. Currently, there is no consensus in the literature regarding the relationship between eQTLs and sQTLs. Genetic control of pre-mRNA splicing (also called sQTLs) is another fundamental mechanism of gene regulation but is heavily underexplored compared to eQTLs. However, only a moderate proportion of GWAS signals have been attributed to cis-eQTLs 14, 15, 16, 17, 18, likely because of various reasons, including limited power, spatiotemporal eQTL effects that occur in specific tissues or cell types at specific developmental stages, focus on genomic regions in cis and mechanisms beyond the genetic control of mRNA abundance. These advances have propelled the development of methods 9, 10, 11, 12, 13 to integrate eQTL data with GWAS data to prioritize the genes responsible for GWAS signals. The effects of genetic variation on messenger RNA abundance (also known as eQTLs) have been studied for more than a decade 5, 6, 7 and nearly all genes have been found with one or more genetic variants associated with their mRNA abundance 6, 8. Considering that most of the GWAS signals are located in noncoding regions of the genome, one hypothesis is that genetic variants affect traits through genetic regulation of gene expression 3, 4. However, most of the trait-associated variants are of uncharacterized function and the mechanisms through which genetic variants exert their effects on traits are largely elusive. GWAS have led to the discovery of tens of thousands of genetic variants associated with human complex traits (including diseases) 1, 2. Our study demonstrates the distinct role of most sQTLs in the genetic regulation of transcription and complex trait variation. Integrating the sQTL data into GWAS for 12 brain-related complex traits (including diseases), we identified 244 genes associated with the traits through cis-sQTLs, approximately 61% of which could not be discovered using the corresponding eQTL data. Applying THISTLE together with a complementary sQTL mapping strategy to brain transcriptomic ( n = 2,865) and genotype data, we identified 12,794 genes with cis-sQTLs at P < 5 × 10 −8, approximately 61% of which were distinct from eQTLs. Here, we introduce an sQTL mapping method, testing for heterogeneity between isoform-eQ TL effects (THISTLE), with improved power over competing methods. Previous studies have shown considerable links of GWAS signals to expression quantitative trait loci (eQTLs) but the links to other genetic regulatory mechanisms, such as splicing QTLs (sQTLs), are underexplored. Most genetic variants identified from genome-wide association studies (GWAS) in humans are noncoding, indicating their role in gene regulation. |
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